Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: Systematic review and meta-analysis
Journal
Lancet Neurology
Journal Volume
4
Journal Issue
6
Pages
371-380
Date Issued
2005
Author(s)
Abstract
Evidence suggests that a high concentration of C-reactive protein (CRP) is a cardiovascular risk factor and an important correlate of cognitive disorders and depression. Recently, population-based studies examining the association between CRP and stroke, cognitive impairment, or depression have been done but have not yet been systematically reviewed. Here we present a systematic review of the associations between CRP and stroke, cognitive impairment, and depression. Hospital or clinic-based studies were excluded because the inferences might not be easily applicable to the general population. 19 eligible studies of CRP were selected: seven for stroke, six for cognitive disorders, and six for depression. Raised CRP concentrations were associated with history of stroke and increased risk of incident stroke. Meta-analysis of studies with long follow-up (>8 years) showed that the risk for stroke in healthy individuals with the highest quartile of CRP concentrations increased nearly 70% compared to those with the lowest quartile. High concentrations of CRP were predictive of cognitive decline and dementia. The relations of CRP to depression were all cross-sectional and were not consistent. We conclude that high concentrations of CRP are associated with increased risk of stroke and cognitive impairment. The association between CRP and depression should be studied prospectively.
SDGs
Other Subjects
C reactive protein; clinical trial; cognitive defect; comparative study; concentration (parameters); dementia; depression; follow up; hospital; human; medical research; MEDLINE; meta analysis; outcomes research; population; priority journal; qualitative analysis; review; risk assessment; stroke; systematic review
Publisher
Lancet Publishing Group
Type
note