Targeted multimodality contrast agent: Synthesis and applications of 18F-labeled targeted perfluorocarbon-filled albumin microbubbles for microUS and microPET
Journal
Proceedings - IEEE Ultrasonics Symposium
Date Issued
2009
Author(s)
Abstract
Targeted albumin shelled microbubbles (MBs) have been applied as a potential drug carrier for the treatment of cancer cells. To provide the pharmacokinetics of the targeted albumin MBs for in vivo therapeutic use of cancer therapy, the multimodality N-succinimidyl-4- [18F] fluorobenzoate (18F-SFB) labeled tumor angiogenesis-related vascular endothelial growth factor receptor 2 (VEGFR2) targeted MBs (tMBs) were synthesized and the biologic characteristics of the tMBs in MDA-MB-231 human breast-cancer-bearing mice were investigated with micro-positron emission tomography (microPET) and high frequency ultrasound (microUS). The efficiency of tMBs targeted to tumor vascular was 14.8% rather than MBs in contrast enhanced microUS. The 18F-labeled tMBs were cleared from blood circulation and accumulated in liver (16.3% ID/g ± 6.8) and lung (5.7 ID/g ±1.6) at 60minutes. Uptake of 18F-labele tMBs was significantly higher in tumor (1.02% ID/g ± 0.3) than in surrounding muscle tissue (0.4% ID/g ± 0.02) at 60minutes. The findings were confirmed with ex vivo biodistribution study. Therefore, 18F-SFB labeled VEGFR2-targeted MBs showed specific tumor uptake in human breast-cancer-bearing mice and could be used as a probe for delivery vehicles in cancer treatment. This study provides useful information for the future clinical application of the multimodality material from imaging to therapeutic levels. ?2009 IEEE.
SDGs
Other Subjects
Cardiovascular system; Diseases; Mammals; Tumors; Clinical application; Contrast-enhanced; High frequency ultrasounds; Human breast cancer; Micro positron emission tomography; Therapeutic levels; Tumor angiogenesis; Vascular endothelial growth factor receptor; Positron emission tomography
Type
conference paper