Dibenzocycloheptanoids from the Leaves of Cinnamomum subavenium
Journal
Journal of Natural Products
Journal Volume
75
Journal Issue
10
Pages
1735-1743
Date Issued
2012
Author(s)
Lin H.-C.
Abstract
Five dibenzocycloheptatrienes (1-3, 5, and 6) and one dibenzocycloheptadiene (8) together with 16 known compounds were isolated from the leaves of Cinnamomum subavenium. Application of HPLC-SPE-NMR to a selected fraction afforded two additional dibenzocycloheptatrienes (4, 7). The glycosides 2-7 comprise two diastereomers because of the chiral glycosyl moiety and the axial chirality of the biphenyl system. Their structures were elucidated via ECD and 2D NMR analyses and chemical degradation. Subavenosides D (5) and E (6) showed moderate inhibitory activity against α-glucosidase type IV from Bacillus stearothermophilus with IC₅₀ values of 50.7 and 19.0 μM, respectively.
Type
journal article