Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation
Journal
Journal of Virology
Journal Volume
85
Journal Issue
12
Pages
6060-6064
Date Issued
2011
Author(s)
Xing S
Bullen C.K
Shroff N.S
Shan L
Manucci J.L
Bhat S
Zhang H
Margolick J.B
Quinn T.C
Margolis D.M
Siliciano J.D
Siliciano R.F.
Abstract
Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 levels to below the detection limit. However, due to the latent reservoir in resting CD4(+) cells, HAART is not curative. Elimination of this reservoir is critical to curing HIV-1 infection. Agents that reactivate latent HIV-1 through nonspecific T cell activation are toxic. Here we demonstrate in a primary CD4(+) T cell model that the FDA-approved drug disulfiram reactivates latent HIV-1 without global T cell activation. The extent to which disulfiram reactivates latent HIV-1 in patient cells is unclear, but the drug alone or in combination may be useful in future eradication strategies.
SDGs
Type
journal article