Expression of Gα12 predicts progression and prognosis of oral squamous cell carcinomas in Taiwan
Journal
Journal of Oral Pathology and Medicine
Journal Volume
42
Journal Issue
7
Pages
565-569
Date Issued
2013
Author(s)
Liu Y.-C.
Cheng S.-L.
Abstract
Background: Expression of Gα12 is found to be associated with cancer cell proliferation, migration, invasion, and metastasis. Methods: This study used immunohistochemistry to examine the expression of Gα12 protein in 100 specimens of oral squamous cell carcinoma (OSCC), 45 specimens of oral epithelial dysplasia (OED), and 36 specimens of normal oral mucosa (NOM). Results: The mean Gα12 labeling indices (LIs, defined as the percentage of positive cells in total cells) increased significantly from NOM (7?±?11%) through OED (21?±?20%) to OSCC samples (53?±?33%, P??50% (P?=?0.009) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, Kaplan-Meier curve showed that OSCC patients with a Gα12 LI?>?50% had a significantly poorer cumulative survival than those with a Gα12 LI???50% (log-rank test, P?=?0.009). Conclusions: Our results showed a stepwise and significant elevation in Gα12 protein expression from NOM through OED to OSCCs, suggesting that overexpression of Gα12 protein may be an early event in oral carcinogenesis and may play a pivotal role in oral cancer development. Moreover, the Gα12 protein can be a biomarker for prediction of the progression of OSCCs and the prognosis of patients with OSCC in Taiwan. ? 2013 John Wiley & Sons A/S.
SDGs
Other Subjects
G alpha 12 protein; G protein coupled receptor; unclassified drug; adult; advanced cancer; aged; alcohol consumption; Areca; article; cancer growth; cancer localization; cancer prognosis; cancer recurrence; cancer size; cancer survival; controlled study; disease severity; female; gene overexpression; human; human tissue; immunohistochemistry; leukoplakia; lymph node metastasis; major clinical study; male; mouth disease; mouth mucosa; mouth squamous cell carcinoma; oral epithelial dysplasia; prediction; priority journal; protein expression; smoking; Taiwan; tongue cancer; cancer progression; G proteins; G-protein-coupled receptor; Gα12; oral cancer; prognosis; Adult; Aged; Aged, 80 and over; Carcinogenesis; Carcinoma, Squamous Cell; Cell Movement; Cell Proliferation; Cytoplasm; Disease Progression; Epithelium; Female; Gene Expression Regulation, Neoplastic; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Lymphatic Metastasis; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Staging; Precancerous Conditions; Prognosis; Survival Rate; Tumor Markers, Biological; Young Adult
Type
journal article