Risk of incident active tuberculosis and use of corticosteroids
Journal
International Journal of Tuberculosis and Lung Disease
Journal Volume
19
Journal Issue
8
Pages
936-942
Date Issued
2015
Author(s)
Abstract
OBJECTIVE : To examine the association between corticosteroid use and risk of active tuberculosis (TB) disease. METHODS : We conducted a population-based nested case-control study based on Taiwan's National Health Insurance Research Database between January 1999 and December 2011. Each case of incident active TB was matched to 100 controls using a risk-set sampling scheme. RESULT S : From a participant cohort of 1 million, 6229 cases of new active TB and 622 900 controls were identified. Current, recent, past, ever and chronic use of corticosteroids were associated with an increased risk of developing incident active TB, with adjusted rate ratios of respectively 2.76 (95%CI 2.44-3.11), 1.99 (95%CI 1.73-2.31), 1.17 (95%CI 1.06-1.29), 1.60 (95%CI 1.49-1.72), and 1.58 (95%CI 1.43-1.75). For subgroup analysis, the increased risk of TB in chronic corticosteroids users was substantially higher in subjects aged 670 years and female subjects. CONCLUS ION : In this relatively high TB prevalence setting, we found that use of corticosteroids was associated with an increased risk of TB. Current use of corticosteroids was associated with the highest risk of TB. ? 2015 The Union.
SDGs
Other Subjects
amikacin; betamethasone; corticosteroid; cortisone; cycloserine; ethambutol; fludrocortisone; hydrocortisone; isoniazid; kanamycin; methylprednisolone; paramethasone; prednisolone; protionamide; pyrazinamide; rifampicin; streptomycin; triamcinolone; glucocorticoid; adult; Article; cohort analysis; controlled study; disease association; drug use; female; human; incidence; longitudinal study; major clinical study; male; middle aged; national health insurance; population based case control study; priority journal; reimbursement; risk assessment; risk factor; sample size; seroprevalence; social class; Taiwan; tuberculosis; age; aged; case control study; factual database; follow up; incidence; retrospective study; risk factor; sex difference; tuberculosis; Adult; Age Factors; Aged; Case-Control Studies; Databases, Factual; Female; Follow-Up Studies; Glucocorticoids; Humans; Incidence; Longitudinal Studies; Male; Middle Aged; Retrospective Studies; Risk Factors; Sex Factors; Taiwan; Tuberculosis
Type
journal article