Soluble Inflammatory Markers in Coronary Sinus and Peripheral Blood of Heart Transplant Recipients
Date Issued
2002-07-31
Date
2002-07-31
Author(s)
許榮彬
DOI
902314B002422
Abstract
Cardiac allograft rejection is a focal inflammation and soluble markers are released into coronary
sinus (CS). We investigated whether plasma soluble markers in CS is better to predict the clinical
status of transplant recipients than in peripheral blood (PB). Between February 1998 and January
2001, 51 patients admitted for endomyocardial biopsy were included. The clinical events of the
transplant recipient were recorded as: early post-transplant, long-term uneventful status, infection,
acute rejection and transplant coronary artery disease. The plasma levels of interleukin-2 (IL-2),
tumor necrosis factor-(TNF-), ICAM-1, P-selectin, high-sensitive C-reactive protein (CRP) and
troponin-I of CS and PB were determined. There were 71 blood samples. In patients within one
month after heart transplant, there was a higher level of P-selectin, ICAM-1, CRP and troponin-I in
CS and PB. In patients with infection, there was a higher level of all inflammatory markers except
IL-2 in CS and PB. Patients with a long-term uneventful status had a lower level of CRP in PB but
not in CS. In patients with infection, there was a higher level of all soluble markers except IL-2 in
CS and PB. Patients with a long-term uneventful status had a lower level of CRP in PB but not in CS.
Patients with acute rejection had a higher level of IL-2 in PB but not in CS. Patients with transplant
coronary artery disease had a higher level of TNF- in PB but not in CS. Soluble markers in CS
failed to predict the occurrence of acute or chronic rejections.
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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