Collapsin response mediator protein-1: A novel invasion-suppressor gene
Journal
Clinical and Experimental Metastasis
Journal Volume
20
Journal Issue
1
Pages
69-76
Date Issued
2003
Author(s)
Abstract
Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-1 inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-1 mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells.
SDGs
Other Subjects
cell nucleus receptor; collagen response mediator protein 1; matrigel; messenger RNA; neuropilin; proline; protein; semaphorin; T box transcription factor; unclassified drug; advanced cancer; amino acid sequence; cancer inhibition; cancer invasion; cancer recurrence; cancer tissue; depolarization; disease association; filopodium; gene expression; gene function; genetic transcription; genetic transfection; growth cone; human; lung cancer; lymph node metastasis; metastasis; mitosis; multigene family; nonhuman; nuclear localization signal; oncogene; postoperative period; protein function; protein glycosylation; protein modification; protein motif; protein phosphorylation; protein structure; regulatory mechanism; review; RNA translation; signal transduction; suppressor gene; survival time; Endothelial Growth Factors; Genes, Tumor Suppressor; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Mitosis; Neoplasm Metastasis; Nerve Tissue Proteins; Nuclear Localization Signals; Phosphoproteins; Protein Biosynthesis; Protein Processing, Post-Translational; Semaphorin-3A; Semaphorins; Signal Transduction; T-Box Domain Proteins; Transcription, Genetic; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors
Type
review