Family-based association study of SELENBP1 in schizophrenia
Resource
Schizophrenia Research 113 (2-3): 268-272
Journal
Schizophrenia Research
Journal Volume
113
Journal Issue
2-3
Pages
268-272
Date Issued
2009
Author(s)
Kanazawa, Tetsufumi
Glatt, Stephen J.
Faraone, Stephen V.
Yoneda, Hiroshi
Tsuang, Ming T.
Abstract
The SELENBP1 gene previously was found to be up-regulated in microarray analysis of both peripheral blood cell and brain tissue samples from schizophrenia patients. Quantitative PCR analysis subsequently corroborated the altered expression of SELENBP1 in schizophrenia brain tissue samples from the Stanley Array Correction. The aim of this study was to extend those findings by employing family-based association methods to a sample of over 2400 individuals (including 1214 individuals affected by schizophrenia) of Han Chinese descent living in Taiwan. One of four haplotype-tagging SNPs and two different two-marker haplotypes showed nominally significant evidence for association with schizophrenia under an additive model, suggesting that genetic variation in SELENBP1 may influence risk for the disorder, while this significance did not remain when other inheritance models were considered. Further comprehensive analysis with other SNPs and haplotypes is needed and warranted. ? 2009 Elsevier B.V. All rights reserved.
Subjects
Family-based association study; Gene; Schizophrenia; SELENBP1; Selenium binding protein 1 gene
SDGs
Other Subjects
binding protein; selenium binding protein 1; unclassified drug; article; family study; female; genetic association; genetic risk; genetic variability; haplotype; human; major clinical study; male; priority journal; risk assessment; risk factor; schizophrenia; single nucleotide polymorphism; DNA Mutational Analysis; Family Health; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Male; Polymorphism, Single Nucleotide; Schizophrenia; Selenium-Binding Proteins; Taiwan
Type
journal article
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