利用添加物來控制藥物透膜速率－輸送機制之探討
Date Issued
2000
Date
2000
Author(s)
DOI
892214E002036
Abstract
In this work, benzocaine (a hydrophobic drug) was added in the donor cell to enhance the permeation flux of theophylline (a hydrophilic drug) in the EVAc and PU (hydrophobic) membranes. It was observed that the theophylline flux could be greatly enhanced when benzocaine was added in the drug formula. Evidence was obtained showing that the enhancement effect on theophylline flux was originated from the synergetic transport of benzocaine and theophylline. Data were also obtained indicating that the synergetic transport was strongly related to the interaction between the drugs involved. Besides, the addition of surfactants in the drug formula could also change the drug permeation rate. The effect stemmed from that the addition of surfactant could affect the swelling of membranes. Surfactants increasing the degree of swelling would enhance the drug permeation rate. And surfactants decreasing the degree of swelling would have the opposite effect.
Subjects
controlled release
additive
surfactant
synergetic effect
swelling
Publisher
臺北市：國立臺灣大學化學工程學系暨研究所
Type
report
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