Kisspeptin expression in mouse Leydig cells correlates with age
Journal
Journal of the Chinese Medical Association : JCMA
Journal Volume
78
Journal Issue
4
Pages
249
Date Issued
2015-04
Author(s)
Wang, Jyun-Yuan
Hsu, Meng-Chieh
Tseng, Tai-Hsiang
Wu, Leang-Shin
Yang, Kuo-Tai
Abstract
Kisspeptin, encoded by the Kiss1 gene, has many forms including kisspeptin54, kisspeptin14, kisspeptin13, and kisspeptin10, and all these peptides have the same affinity to their receptor KISS1R encoded by the Kiss1r gene. The KISS1-KISS1R system was discovered in neurons, and many reports stress on their function in the brain. However, recent studies have shown that Kiss1 and Kiss1r are expressed in the testes. The goal of this study was to demonstrate the roles of Kiss1 and Kiss1r in testicular function, especially their steroidogenic activity.
Subjects
Leydig cells; kisspeptin; puberty; steroidogenesis
SDGs
Other Subjects
kisspeptin; kisspeptin 1 receptor; kisspeptin 10; peptide; peptide234; receptor; testosterone; unclassified drug; 3(or 17)beta hydroxysteroid dehydrogenase; cholesterol monooxygenase (side chain cleaving); estrogen receptor alpha; G protein coupled receptor; Kiss1 protein, mouse; Kiss1r protein, mouse; kisspeptin; testosterone; adult; animal cell; Article; body weight; controlled study; gene expression; gonadosomatic index; Leydig cell; male; male genital tract parameters; mouse; nonhuman; protein expression; steroidogenesis; testis; testis function; testis weight; testosterone blood level; age; animal; blood; cell culture; genetics; Institute for Cancer Research mouse; Leydig cell; physiology; 3-Hydroxysteroid Dehydrogenases; Age Factors; Animals; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Estrogen Receptor alpha; Kisspeptins; Leydig Cells; Male; Mice; Mice, Inbred ICR; Receptors, G-Protein-Coupled; Testosterone
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Type
journal article