Noradrenergic Enhancement of Motor Learning, Attention, and Working Memory in Humans
Journal
The international journal of neuropsychopharmacology
Journal Volume
24
Journal Issue
6
Pages
490
Date Issued
2021
Author(s)
Abstract
Noradrenaline has an important role as a neuromodulator of the central nervous system. Noradrenergic enhancement was recently shown to enhance glutamate-dependent cortical facilitation and long term potentiation-like plasticity. As cortical excitability and plasticity are closely linked to various cognitive processes, here we aimed to explore whether these alterations are associated with respective cognitive performance changes. Specifically, we assessed the impact of noradrenergic enhancement on motor learning (serial reaction time task), attentional processes (Stroop interference task), and working memory performance (n-back letter task).
Subjects
Attention; memory; motor learning; noradrenaline; reboxetine
SDGs
Other Subjects
placebo; reboxetine; adrenergic receptor affecting agent; nootropic agent; noradrenalin; reboxetine; adult; Article; attention; cognitive flexibility; crossover procedure; female; human; human experiment; male; motor learning; noradrenergic system; normal human; selective attention; sequence learning; serial reaction time; single drug dose; Stroop test; working memory; attention; drug effect; learning; motor activity; short term memory; young adult; Adrenergic Uptake Inhibitors; Adult; Attention; Cross-Over Studies; Female; Humans; Learning; Male; Memory, Short-Term; Motor Activity; Nootropic Agents; Norepinephrine; Reboxetine; Young Adult
Publisher
OXFORD UNIV PRESS
Type
journal article