鼻咽癌與DNA修補基因之流行病學研究 (第二年)
Date Issued
2003-07-31
Date
2003-07-31
Author(s)
鄭玉娟
DOI
912320B002194
Abstract
Genetic polymorphisms of DNA repair
genes have been reported to determine
susceptibility to several cancers. This study
focused on effects of genetic polymorphisms of
DNA repair genes XPD condon751 and p21 on
the development of nasopharyngeal carcinoma (NPC). The incidence of nasopharyngeal carcinoma
in Chinese is the highest in the world. It is
20-30 times compared to Caucasian, and even
much more than Japanese and Korean.
Compared to other cancers, the peak of
nasopharyngeal carcinoma occurs more
frequently in younger age and dominant in
male. The impact of the disease especially can
not be ignored. The specific aim of this study is
to explore the risk factors of nasopharyngeal
carcinoma (NPC). A case-control study of NPC
which was collaborated with College of
Medicine, College of Public Health National
Taiwan University and the National Institute of
Health in America was conducted in Taiwan
from July 1991 to December 1994 to
investigate the interaction of environmental
carcinogen and genotype polymorphism to the
risk of NPC. Totally 334 histologically
confirmed incident NPC cases who were
younger than 75 year old, had no prior
diagnosis or treatment for NPC, and had
resided in Taipei city/county for at least 6
months, were prospectively recruited from
National Taiwan University Hospital and
Mackay Memorial Hospital. Totally 283
healthy community controls were selected by
individual matching for sex, age and residence.
The study will use the real-time polymerase
chain reaction (RTPCR) to analyze the gene
types of DNA repair genes XPD and p21.
Risk factor information was obtained
through personal interview with structured
questionnaire. The information from questionnaire such as demographic factors, the
history of smoking, drinking, dietary habit,
family history of cancer etc. and the results of
genetic polymorphisms of DNA repair from
specimen testing were combined to evaluate the
effect to NPC simultaneously. Unconditional
logistic regression was performed to clarify the
relationship between various risk factors,
genetic susceptibility and NPC and to elucidate
their interaction. After adjusting age, sex,
ethnicity, educational level, and duration of
smoking, no association were observed for
genetic polymorphisms of XPD condon751 、
p21. We further stratified by anti-EBV
antibodies, occupational exposure to wood dust
and formaldehyde, and dietary nitrosamine
intake; but there remained no significant
association between NPC risk and metabolic
gene polymorphisms.
Subjects
nasopharyngeal carcinoma
case-control study
risk
factor
factor
DNA repair genes
genetic polymorphism
susceptibility
SDGs
Publisher
臺北市：國立臺灣大學公共衛生學院流行病學研究所
Type
report
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