Permanent neonatal diabetes mellitus manifesting as diabetic ketoacidosis
Journal
Journal of the Formosan Medical Association
Journal Volume
102
Journal Issue
12
Pages
883-886
Date Issued
2003
Abstract
Neonatal diabetes mellitus (NDM) is very rare disease defined as hyperglycemia that occurs during the first month of life, requires insulin treament, and lasts more than 2 weeks. There are 2 types of NDM: permanent neonatal diabetes mellitus (PNDM) and transient neonatal diabetes mellitus (TNDM). We report a case of PNDM in a 3-day-old female infant. This full-term neonate was born small gestational age. Respiratory distress, poor activity, hypothermia, poor feeding, dehydration, and ketoacidosis were noted at the age of 3 days. After insulin therapy and fluid replacement, her condition became stable. Glucagon test done at the age of 26 days showed serum C-peptide level to be low for her age. During the first year of life she had catch-up growth, but insulin therapy was still required. Serum C-peptide level was undertectable at the age of 15 months. The course of this case indicates the important and facilitate normal growth and development under insulin therapy.
SDGs
Other Subjects
C peptide; glucagon; glucose; isophane insulin; article; case report; catch up growth; child development; child growth; clinical feature; dehydration; diabetes mellitus; diabetic ketoacidosis; disease course; disease duration; feeding disorder; female; fluid therapy; human; hyperglycemia; hypothermia; infant; physical activity; respiratory distress; small for date infant; treatment outcome; Diabetes Mellitus; Diabetic Ketoacidosis; Diagnosis, Differential; Female; Humans; Infant, Newborn
Type
journal article