Mapping of Psoriasis to 17q Terminus
Resource
JOURNAL OF MEDICAL GENETICS v.42 n.2 pp.152-158
Journal
JOURNAL OF MEDICAL GENETICS
Journal Volume
v.42
Journal Issue
n.2
Pages
152-158
Date Issued
2005
Date
2005
Author(s)
HWU, WUH-LIANG
FANN, CATHY SHENG-JIUAN
TSAI, TSEN-FANG
CHIEN, YIN-HSIU
CHIANG, SHU-CHUAN
WU, JER-YUARN
CHEN, YUAN-TSONG
Abstract
Psoriasis is a chronic, inflammatory, hyperproliferative disease of the skin, scalp, nails, and joints, with a prevalence of up to 2% in Caucasians1,2 but well under 1% in the Mongoloid races of the Far East.3 The disease varies in severity. Some patients display mild disease with isolated scaling erythematous plaques on the elbows or knees, whereas for others most of their cutaneous surface can be affected. At the cellular level, psoriasis is characterised by markedly increased epidermal proliferation and incomplete differentiation, elongation, dilation, and leakiness of the superficial plexus of dermal capillaries, and by a mixed inflammatory and immune cell infiltrate of the epidermis and papillary dermis.1,2 Dermal infiltrates comprised of T cells and macrophages typically appear in early lesions before epidermal changes.4 The therapeutic effect of immunosuppressive agents suggests psoriasis has a primary immune pathogenic basis.5 inflammatory and immune cell infiltrate of the epidermis and papillary dermis.1,2 Dermal infiltrates comprised of T
Subjects
psoriasis
PSORS2
genome-wide scan
17q terminus
tubulin- specific chaperone d gene
Type
journal article