Treatment Efficacy of Electromagnetic Thermotherapy Used in Small Animals and Consequent Hematological Changes in Peripheral Bloods

Thermal ablation is a local application that uses extreme temperature to induce cell injury. It is a new modality for cancer treatment and popped up with advanced technology since 1990s. Electromagnetic thermotherapy system that we used in this study is designed by National Cheng Kung University. This newly developed system pertain advantages of not only shortened surgical time and less bleeding during operation by rapid high temperature but also no limitation on the total numbers of inserted needles. In this clinical trial between 2014 and 2016, total 21 patients were recruited and treated with tumor types including 8 oral tumors, 7 superficial soft tissue sarcomas, 3 hepatic tumors and 3 feline injection-site sarcomas. At the end of our trial, 8 (38%) patients were still in complete remission and 2 (10%) were in partial remission. Of the 21 patients, median overall survival time was 279 days and median progression free interval was 225 days. The median tumor specific survival time for the 18 patients was 296 days. In conclusions, patients with extremity STS had a better treatment efficacy and Progression free interval in the present study. Tumor-related adverse effects were mainly seen in superficial tumors with deep subcutaneous and soft tissue damage. During the follow up recheck time, no hematological changes were observed. A well-design study for specific tumor type or well-defined clinical staging underwent EMT treatment and synergic with T cell population analysis. may be required in order to apply in clinical setup.