Design and Development of Pneumatic Micro-dose Nebulizer with Optical Dosage Monitoring
Date Issued
2015
Date
2015
Author(s)
Chen, Yu-Ming
Abstract
Optical measurement systems are widely used in the field of chemistry and medical appliances due to the advantage of non-invasive, high resolution, and high accuracy. The Shack-Hartmann Wavefront sensor (SHWS) can precisely detect the optical path difference(OPD) and is successfully applied to measure the eye contour. This paper presents the development of a new application of SHWS in the nebulization concentration measurement, which can quantify mist and transmit a given dose of the mist. This measuring system is desperately needed in medical applications. A mist dosage system is presented in this paper, which consist of two parts, the mist generating system and package transmit system. By setting the pressure to 0.3 bar and manipulate the pressure frequency 3 to 7 Hz, the package frequency and the mist mass flow rate can be controlled. Each mist package is about 0.2 mg. Also, the optical measuring system is developed. The Shack-Hartmann wavefront sensor is used to measure the mist, which generated by the mist dosage system. The Shannon entropy is a way to measure a system’s uncertainty, which can be used to analyze the SHWS’s data. The experimental verifications have found that the Shannon entropy of spot field images and Zernike coefficients are changed in proportional to the nebulization concentration. Basing on these experiment, spot offset analyzing method and Zernike coefficient analyzing method has been developed. By using the spot offset analyzing method, the coefficient of determination can approach to 0.8548. The resolution of the mist’s mass flow rate is 1 mg/s. The coefficient of determination is 0.3994 by using the Zernike coefficient analyzing method, which is much lower than the spot offset analyzing method.
Subjects
Micro-dose nebulizer
package
Shack-Hartmann wavefront sensor
uncertainty analyzation
light spot shift
Zernike coefficients
Type
thesis
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