Drug transport mechanism in polymeric membranes
Date Issued
1999
Date
1999
Author(s)
DOI
882214E002003
Abstract
In the present work, the effect of
membrane swelling on the diffusivity of drugs
was investigated theoretically and
experimentally. On basis of the Flory-Huggins
and Yasuda theories, a perturbation procedure
was used to expand the logarithm of
diffusivity in powers of the activity of
swelling agent. Similarly, the logarithm of
diffusivity can also be expressed in powers of
the volume fraction of swelling agent in the
swollen membrane. In addition, experiments of measuring the diffusivity of drugs were
performed. The membrane used was the
poly(ethylene-co-vinylacetate) and poly-urethane
membranes. The swelling agent was
ethanol, and water was added to adjust the
activity of ethanol and the swelling ability.
The diffusivities of benzocaine, nitroglycerin,
and ethanol were measured. It was found that
the logarithm of the measured diffusivity
increases linearly with increasing ethanol
activity. On the other hand, for the dependence
of the logarithm of diffusivity on the volume
fraction of ethanol, the quadratic term is
required to bring about good agreement
between experimental data and theoretical
calculation. Therefore, it seems more
convenient to use the dependence of
diffusivity on the activity of swelling agent
than to use the dependence on the volume
fraction of the swelling agent.
Subjects
controlled release
swelling
diffusion
polymeric membrane
drug transport
Publisher
臺北市：國立臺灣大學化學工程學系暨研究所
Type
report
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