The synergistic effect of chemo-photothermal therapies in SN-38-loaded gold-nanoshell-based colorectal cancer treatment
Journal
Nanomedicine
Journal Volume
17
Journal Issue
1
Pages
23-40
Date Issued
2022
Author(s)
Abstract
Aim: 7-Ethyl-10-hydroxycamptothecin (SN-38)-loaded gold nanoshells nanoparticles (HSP@Au NPs) were developed for combined chemo-photothermal therapy to treat colorectal cancer. Materials & methods: SN-38-loaded nanoparticles (HSP NPs) were prepared by the lyophilization-hydration method, and then developed into gold nanoshells. The nanoparticles were characterized and assessed for photothermal properties, cytotoxicity and hemocompatibility in vitro. In vivo anticancer activity was tested in a tumor mouse model. Results: The HSP@Au NPs (diameter 186.9 nm, zeta potential 33.4 mV) led to significant cytotoxicity in cancer cells exposed to a near-infrared laser. Moreover, the HSP@Au NP-mediated chemo-photothermal therapy displayed significant tumor growth suppression and disappearance (25% of tumor clearance rate) without adverse side effects in vivo. Conclusion: HSP@Au NPs may be promising in the treatment of colorectal cancer in the future. © 2021 Future Medicine Ltd.
Subjects
7-ethyl-10-hydroxycamptothecin; chemotherapy; colorectal cancer; gold nanoshell; human serum albumin; multifunctional therapy; near-infrared laser; photothermal therapy; polyethylenimine
SDGs
Other Subjects
doxorubicin; irinotecan; nanoshell; animal; colorectal tumor; mouse; phototherapy; photothermal therapy; tumor cell line; Animals; Cell Line, Tumor; Colorectal Neoplasms; Doxorubicin; Irinotecan; Mice; Nanoshells; Phototherapy; Photothermal Therapy
Type
journal article