Investigation of Corneal Wound Healing by in vivo Confocal Microscopy
Date Issued
2010
Date
2010
Author(s)
Ko, Pei-Shaw
Abstract
Corneal regeneration plays an important role in corneal wound healing in human and veterinary ophthalmology. In vivo confocal microscopy was used to observe the corneal epithelial cells during corneal wound healing. In the present study, the corneal wounds of diabetic patients who underwent corneal epithelial debridement during pars plana vitrectomy for proliferative diabetic retinopathy were investigated. In vivo confocal microscopy was used to evaluate images of the corneal basal and apical surface epithelial cells before surgery weekly for the first month, and at the third and sixth month after surgery, respectively. In vivo confocal microscopy showed incomplete healing of basal epithelial cells in 72.1%, 15.2%, and 0% of eyes and incomplete healing of surface apical epithelial cells in 81.1%, 9.1%, and 0% of eyes at 1, 3, and 6 months after surgery, respectively. The tortuous morphology of subbasal corneal nerves were observed in diabetic patients and STZ-induced diabetic rats. The results revealed the slower corneal regeneration process in the diabetic patients than non-diabetic patients.
Subjects
in vivo confocal microscopy
corneal wound healing
diabetics
SDGs
Type
thesis
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