Corylin suppresses hepatocellular carcinoma progression via the inhibition of epithelial-mesenchymal transition, mediated by long noncoding RNA GAS5
Journal
International Journal of Molecular Sciences
Journal Volume
19
Journal Issue
2
Pages
380
Date Issued
2018
Author(s)
Abstract
Corylin is a flavonoid extracted from the nuts of Psoralea corylifolia L. (Fabaceae), which is a widely used anti-inflammatory and anticancer herb in China. Recent studies revealed antioxidant, anti-inflammatory, and bone differentiation-promoting effects of corylin. However, there are no studies examining the anticancer activity of corylin. In this study, we used cells and animal models to examine the antitumor effects of corylin on hepatocellular carcinoma (HCC) and then studied its downstream regulatory mechanisms. The results showed that corylin significantly inhibited the proliferation, migration, and invasiveness of HCC cells and suppressed epithelial-mesenchymal transition. We found that the anti-HCC mechanism of corylin’s action lies in the upregulation of tumor suppressor long noncoding RNA growth arrest-specific transcript 5 (GAS5) and the activation of its downstream anticancer pathways. In animal experiments, we also found that corylin can significantly inhibit tumor growth without significant physiological toxicity. The above results suggest that corylin has anti-HCC effects and good potential as a clinical treatment. ? 2018 by the authors. Licensee MDPI, Basel, Switzerland.
SDGs
Other Subjects
antineoplastic agent; corylin; flavonoid; long noncoding RNA growth arrest specific transcript 5; long untranslated RNA; unclassified drug; antineoplastic agent; corylin; flavonoid; growth arrest specific transcript 5; small nucleolar RNA; animal experiment; animal model; animal tissue; antineoplastic activity; antiproliferative activity; Article; cancer inhibition; controlled study; drug mechanism; epithelial mesenchymal transition; in vitro study; in vivo study; liver cell carcinoma; male; metastasis inhibition; mouse; nonhuman; tumor invasion; upregulation; animal; Bagg albino mouse; drug effect; epithelial mesenchymal transition; genetics; Hep-G2 cell line; human; liver cell carcinoma; liver tumor; nude mouse; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Epithelial-Mesenchymal Transition; Flavonoids; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; RNA, Small Nucleolar
Publisher
MDPI AG
Type
journal article