細胞趨化性激素在抵抗肺組織胞漿菌炎之保護效性
Date Issued
2005
Date
2005
Author(s)
伍安怡
DOI
932320B002076
Abstract
In respiratiory infections, activated T cells are recruited into the lungs where they
exert effector functions. The T cells are activated and expand in the lung-associated
lymph nodes following a respiratory infection. The differentiated T cells migrate from
the lymph nodes to the lung. Our study showed that mouse with pulmonary
histoplasmosis mount a type 1 T cell response, and granuloma was formed in infected
lungs with infiltrating cells. The expression of IP-10 protein is reported in the airway
of tuberculosis patients. Since IP-10 and other IFN-γ inducible chemokines, Mig and
I-TAC are important in the recruitment of activated T cells, especially Th-1 cells, we
hypothesize that CXCR3 expression on activated Th1 cells in the pulmonary infection
model directs the migration of differentiated T cell from lung-associated lymph nodes
to the lung.
Using pulmonary histoplasmosis animal model, we studied the kinetics of the
expression of Th1-associated chemokines in the infection. In addition, CXCR3 -/-
mice were used to study trafficking of activated Th1 T cells as well as other immune
cells from lymph node to their target organ. We found that fungal clearance in
pulmonary histoplasmosis is not significantly affected by CXCR3 deficiency.
However, in CXCR3-deficient mice, the number of NK cells is reduced in the
draining lymph node of lungs, indicating that NK cell migration to the lymph node in
pulmonary infection is CXCR3-dependent. In systemic infection, depletion of
CXCR3 ligand IP-10 and CCR5 ligand RANTES in wild type mice increased the
fungal burdens at day 7 and day 14, respectively, after infection. The results indicate
that IP-10 is involved in the early phase of histoplasmosis when NK cells are involved
in host defense while RANTES contributes to the later phase of infection when
activated T cells are recruited for fungal clearance.
SDGs
Publisher
臺北市：國立臺灣大學醫學院免疫學研究所
Type
journal article
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