Synthesis of thermo-sensitive acrylate hydrogels and its controlled drug release study

本實驗以兩種系統來製備壓克力系(acrylic)共聚水膠，經由改變共聚水膠粉末的中和程度及交聯度…等，以獲得不同結構型態及物理性質之水膠，並藉由不同的水膠結構設計及物理性質，探討複合膠體於藥物控制釋放系統之適用性。
本研究以丙烯酸(AA)、丙烯酸鈉(SA，sodium acrylate)及丙烯酸2-乙基己酯(2-EHA)單體為主，以乳化聚合方式合成具交聯之poly(AA-co-SA)及poly(AA-co-SA-co-EHA)次微米級乳膠顆粒粉末，摻混次微米級黏著性乳膠顆粒，觀察所合成之乳膠顆粒型態，並以鋁離子(Al3+)與羧酸基(carboxyl group，COO-)交聯成膜後，觀察不同的水膠型態、中和程度、交聯度對膨潤性質及初期黏性的影響。而後再摻混溫度敏感型micro-gel後，以咖啡因為模擬藥物，進行藥物釋放控制研究，觀察摻混不同溫度敏感型乳液對藥物控制釋放之影響。

In this research, acrylic hydrogels were manufactured by two systems. By changing several variables such as the degree of neutralization or the concentration of crosslinking agent, the synthesized hydrogels showed different structures and physical properties. The application of the hydrogel film in drug release was discussed.
Acrylic acid, sodium acrylate, and 2-ethylhexyl acrylate were used to synthesize the crosslinked poly(AA-co-SA) and poly(AA-co-SA-co-EHA) latex particles by emulsion polymerization. Then, by blending the sub-micron adhesive latex particles and using aluminum ion to interact with carboxyl group, the swelling ratio and initial adhesiveness of different structures of the hrdrogel films were observed. Furthermore, adding different kinds of thermo-sensitive micro-gels into the above latex system, and caffeine as a model drug, the drug release behavior and the thermo-sensitivity of the hydrogel films were examined.