The in vivo performance of biomagnetic hydroxyapatite nanoparticles in cancer hyperthermia therapy
Journal
Biomaterials
Journal Volume
30
Journal Issue
23-24
Pages
3956-3960
Date Issued
2009
Author(s)
Abstract
Hyperthermia therapy for cancer has drawn more and more attention these days. In this study, we conducted an in vivo cancer hyperthermia study of the new magnetic hydroxyapatite nanoparticles by a mouse model. The magnetic hydroxyapatite nanoparticles were first made by co-precipitation method with the addition of Fe2+. Then, magnetic-HAP powder (mHAP) or pure HAP powder (HAP) was mixed with phosphate buffer solution (PBS), respectively. The mixture was injected around the tumor. In order to achieve hyperthermia, the mice were placed into an inductive heater with high frequency and alternating magnetic field. Only the mice which were injected with mHAP and had been treated inside the magnetic field showed dramatic reduction of tumor volume, in the 15-day observation period. No local recurrence was noted. The blood test of mice proved that mHAP powders possessed good biocompatibility and little toxicity when injected subcutaneously. Therefore, our new magnetic hydroxyapatite nanoparticles have demonstrated therapeutic effect in a mouse model with little toxicity. Further study should be done before its application inside the human body. ? 2009 Elsevier Ltd. All rights reserved.
SDGs
Other Subjects
Alternating magnetic field; Blood test; Coprecipitation method; High frequency; Human bodies; Hydroxyapatite composite; In-vivo; Local recurrence; Mouse models; Observation Period; Phosphate buffer solutions; Therapeutic effects; Tumor volumes; Apatite; Biocompatibility; Biomagnetism; Chemotherapy; Electromagnetic field effects; Hazardous materials; Hyperthermia therapy; Magnetic fields; Magnetic materials; Nanocomposites; Nanoparticles; Powders; Precipitation (chemical); Toxicity; Tumors; Hydroxyapatite; hydroxyapatite; nanoparticle; phosphate buffered saline; animal experiment; animal model; article; biocompatibility; biomagnetism; colorectal cancer; controlled study; hyperthermia; hyperthermic therapy; magnetic field; mouse; nonhuman; precipitation; priority journal; tumor volume; Animals; Cell Line, Tumor; Durapatite; Hyperthermia, Induced; Magnetics; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasms; Mus
Type
journal article