Mitochondria in the Pathogenesis of Systemic Lupus Erythematosus
Journal
Current rheumatology reports
Journal Volume
24
Journal Issue
4
Pages
88
Date Issued
2022-04
Author(s)
Tsokos, George C
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production and inflammation in multiple organs. In this article, we present data on how various mitochondria pathologies are involved in the pathogenesis of the disease including the fact that they serve as a reservoir of autoantigens which contribute to the upending of lymphocyte tolerance.
Subjects
Lupus; Mitochondria; SLE
SDGs
Publisher
SPRINGER
Type
review