Involvement of 14-3-3γ overexpression in extrahepatic metastasis of hepatocellular carcinoma
Journal
Human Pathology
Journal Volume
42
Journal Issue
1
Pages
129-135
Date Issued
2011
Author(s)
Abstract
The 14-3-3γ protein is an important regulator of various cellular and physiologic functions. Overexpression promotes cell proliferation and induces cancer cell polyploidization. Production is up-regulated in human hepatocellular carcinoma. However, the clinical significance of 14-3-3γ for human hepatocellular carcinoma metastasis and survival has not been clarified. In this study, 55 patients with human hepatocellular carcinoma were enrolled; and 18 of them were identified as having extrahepatic metastases. Expression of 14-3-3γ in these primary and metastatic samples was measured with semiquantitative immunohistochemistry analysis. Overexpression of 14-3-3γ was observed in 38 (69.1%) of the primary tumors, correlated significantly with a high α-fetoprotein concentration (P = .003), and predicted a higher probability of extrahepatic metastasis (cumulative probabilities at 5 years: 42.2% ± 8.0% versus 5.9% ± 5.7%, 14-3-3γ positive versus negative; P = .012). Furthermore, 14-3-3γ overexpression was associated with a worse 5-year overall survival rate (81.6% ± 9.6% versus 59.5% ± 8.1%, respectively) and a worse 5-year progression-free survival rate (75.6% ± 10.6% versus 48.6% ± 8.2%, respectively). Elevated expression of 14-3-3γ in human hepatocellular carcinoma predicts extrahepatic metastasis and worse survival. The protein thus is a candidate biomarker and a potential target for novel therapies against human hepatocellular carcinoma progression and metastasis. ? 2011 Elsevier Inc. All rights reserved.
SDGs
Other Subjects
alpha fetoprotein; biological marker; protein 14 3 3; protein 14 3 3gamma; unclassified drug; adult; article; cancer survival; controlled study; female; human; immunohistochemistry; liver cell carcinoma; major clinical study; male; metastasis; overall survival; prediction; probability; progression free survival; protein expression; survival rate; 14-3-3 Proteins; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Prognosis; Survival Rate
Type
journal article