Use of Caenorhabditis elegans to Study the Potential Bioactivity of Natural Compounds
Journal
Journal of Agricultural and Food Chemistry
Journal Volume
66
Journal Issue
8
Pages
1737-1742
Date Issued
2018
Author(s)
Abstract
There is growing need and interest in finding specific compounds in natural products that have health benefits. Despite ongoing efforts to discover such compounds, the scientific evidence lags behind the vision, and it is important to find an effective paradigm for discovering such compounds. The model organism Caenorhabditis elegans offers a promising solution for studying the potential bioactivity and molecular mechanisms of natural compounds in vivo. This perspective discusses its use to study potential human health benefits, with focus on antioxidative, anti-aging, antimetabolic disorders (diabetes and obesity), and antineurodegenerative activities (Alzheimer's disease and Parkinson's disease), with practical examples. Finally, future directions in using a C. elegans-based model for discovering bioactive compounds for health promotion are discussed. ? 2018 American Chemical Society.
Subjects
bioactivity; Caenorhabditis elegans; health benefits; in vivo; natural compounds
SDGs
Other Subjects
Bioactivity; Neurodegenerative diseases; Alzheimer's disease; Bioactive compounds; Caenorhabditis elegans; Health benefits; In-vivo; Natural compounds; Parkinson's disease; Scientific evidence; Health; antidiabetic agent; antioxidant; biological product; aging; animal; Caenorhabditis elegans; disease model; drug effects; human; physiology; Aging; Animals; Antioxidants; Biological Products; Caenorhabditis elegans; Disease Models, Animal; Humans; Hypoglycemic Agents
Type
journal article