High hepatitis C viral load and genotype 2 are strong predictors of chronic kidney disease
Journal
Kidney International
Journal Volume
92
Journal Issue
3
Pages
703-709
Date Issued
2017
Author(s)
Lee M.-H.
Yang H.-I.
You S.-L.
Lu S.-N.
Wang L.-Y.
Yuan Y.
L'Italien G.
Chen C.-J.
REVEAL-HCV Study Group
Abstract
Associations between chronic hepatitis C virus (HCV) infection and chronic kidney disease (CKD) remain controversial. Here we aimed to clarify the association between HCV viral load, genotype, and CKD in 13,805 participants aged 30-65 years enrolled in the REVEAL-HCV Study, a community-based prospective study conducted in 1991-1992. CKD was defined by consecutive proteinuria or an estimated glomerular filtration rate (eGFR) under 60 mL/min/1.73 m2. Chronic HCV infection was defined by detectable HCV viral load. Logistic regression models were used to estimate prevalence odds ratio of CKD for chronic HCV infection after adjusting for other risk factors. Compared to non-chronically HCV-infected participants, the adjusted prevalence odds ratio (95% confidence interval) for CKD was significantly increased to 1.91 (1.27–2.88) for chronically HCV-infected participants. Compared to non-chronically HCV-infected participants, the adjusted prevalence odds ratio of CKD was 1.21 (0.54-2.70), 1.40 (0.66-3.00) and 3.44 (1.92-6.14) for chronically HCV-infected participants with low to high tertiles of serum HCV RNA, respectively. The adjusted prevalence odds ratios of CKD were 0.54 (0.17-1.75) for participants with low HCV RNA and genotype 1, 1.80 (0.84-3.87) for those with low HCV RNA and genotype 2, 2.62 (1.11-6.17) for those with high HCV RNA and genotype 1 and 4.99 (2.25-11.06) for those with high HCV RNA and genotype 2, compared with non-chronically HCV-infected participants. Thus, chronic HCV infection is associated with an increased risk of CKD. High HCV viral load and HCV genotype 2 are strong CKD predictors. ? 2017 International Society of Nephrology
SDGs
Other Subjects
adult; Article; chronic hepatitis C; chronic kidney failure; cohort analysis; controlled study; disease association; estimated glomerular filtration rate; female; follow up; Hepatitis C virus genotype 1; Hepatitis C virus genotype 2; human; informed consent; major clinical study; male; nonhuman; prevalence; priority journal; prospective study; virus load; blood; chronic hepatitis C; chronic kidney failure; genotype; glomerulus filtration rate; Hepacivirus; isolation and purification; liver function test; middle aged; odds ratio; physiology; proteinuria; risk factor; statistical model; Taiwan; urine; virology; virus RNA; Adult; Female; Genotype; Glomerular Filtration Rate; Hepacivirus; Hepatitis C, Chronic; Humans; Liver Function Tests; Logistic Models; Male; Middle Aged; Odds Ratio; Prevalence; Prospective Studies; Proteinuria; Renal Insufficiency, Chronic; Risk Factors; RNA, Viral; Taiwan; Viral Load
Publisher
Elsevier B.V.
Type
journal article