Red blood cell distribution width and risk of cardiovascular events and mortality in a community cohort in Taiwan
Journal
American Journal of Epidemiology
Journal Volume
171
Journal Issue
2
Pages
214-220
Date Issued
2010
Author(s)
Abstract
The authors investigated whether red blood cell distribution width (RDW) was associated with the development of cardiovascular disease (CVD) events and mortality in a community cohort in Taiwan. The influence of anemia on the association was also assessed. RDW levels were measured in 3,226 participants aged 35 years or older who reported no CVD or cancer at baseline in 1990. During a median follow-up period of 15.9 years (1990-2007), 358 participants experienced stroke and/or coronary heart disease, and 810 participants died. The multivariateadjusted hazard ratio for subjects in the highest RDW quartile as compared with the lowest quartile was 1.46 for both all-cause mortality (95% confidence interval: 1.17, 1.81) and non-CVD mortality (95% confidence interval: 1.13, 1.88) (P for trend < 0.01 for both) but was not significant for CVD morbidity and mortality. Further analyses showed that in comparison with participants with low RDW and no anemia, persons with high RDW but no anemia had elevated risks of all-cause mortality and non-CVD mortality. The authors conclude that elevated RDW values are associated with increased risk of mortality but not the development of CVD in the general population. RDW may precede anemia in predicting the risk of non-CVD death.
SDGs
Other Subjects
anemia; blood; cardiovascular disease; cohort analysis; cytology; health risk; morbidity; mortality risk; adult; anemia; article; blood cell count; cardiovascular disease; cardiovascular risk; disease association; erythrocyte; female; follow up; human; human cell; ischemic heart disease; major clinical study; male; mean corpuscular volume; mortality; stroke; Taiwan; Adult; Anemia; Cardiovascular Diseases; Cell Size; Erythrocytes; Female; Humans; Male; Middle Aged; Risk Factors; Taiwan; Taiwan
Type
journal article