Components of cardiometabolic risk factors predict liver-related events in patients cured of hepatitis C Virus.
Journal
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
Journal Volume
59
Journal Issue
2
Start Page
181
End Page
187
ISSN
1995-9133
Date Issued
2026-04
Author(s)
Hsu, Wei-Fan
Lai, Hsueh-Chou
Wang, Hung-Wei
Chen, Sheng-Hung
Su, Wen-Pang
Chen, Hung-Yao
Peng, Cheng-Yuan
Abstract
Background: The new nomenclature of steatotic liver disease (SLD) was proposed in June 2023. The effects of cardiometabolic risk factors (CMRFs) on liver-related events (LREs) in patients achieving chronic hepatitis C (CHC) eradication are unknown. Methods: This study recruited 1185 patients cured of CHC. CMRFs and alcohol consumption were clearly defined. Variables obtained at 12 or 24 weeks after direct-acting antiviral therapy (PW12) were used to identify the predictors of LREs. Results: A total of 562 patients (47.4 %) had metabolic dysfunction–associated SLD (MASLD), 96 (8.1 %) had MASLD with increased alcohol intake, 14 (1.2 %) had alcohol-related liver disease, 78 (6.6 %) had cryptogenic SLD, and 435 (36.7 %) had no SLD. Multivariable Cox regression analysis indicated that age, alcohol consumption, per CMRF (hazard ratio: 1.332, 95 % confidence interval: 1.094–1.621), posttreatment albumin level, alpha-fetoprotein level, and fibrosis-4 index >3.25 were independent predictors of LREs. Another multivariable analysis revealed that prediabetes and diabetes mellitus were predictors of LREs. Conclusions: The new fatty liver disease nomenclature of SLD was used to stratify the risk of LREs in patients achieving CHC eradication. The risk of LREs increased by 33 % per CMRF, and prediabetes or DM was a predictor of LREs.
Subjects
Chronic hepatitis C
Hepatocellular carcinoma
Liver-related event
Steatotic liver disease
Viral eradication
Type
journal article