Nuclear Expression of Glioma-Associated Oncogene Homo log 1 and Nuclear Factor-kappa B Is Associated with a Poor Prognosis of Pancreatic Cancer
Resource
Oncology, 85(2), 86-94
Journal
Oncology
Journal Volume
85
Journal Issue
2
Pages
86-94
Date Issued
2013
Date
2013
Author(s)
Yang, Shih-Hung
Hsu, Chih-Hung
Lee, Jen-Chieh
Tien, Yu-Wen
Kuo, Sung-Hsin
Cheng, Ann-Lii
Abstract
Objective: We investigated the association of the hedgehog pathway with nuclear factor (NF)-kappa B and clinical outcomes in pancreatic cancer patients. Methods: We analyzed tissue samples for the expression of NF-kappa B (RelA/p65), sonic hedgehog (Shh) and glioma-associated oncogene homolog 1 (Gli1) by immunohistochemistry and investigated their expression in association with clinical outcomes. Results: Eighty-one patients with pancreatic cancer were investigated. Expression of Shh and nuclear expression of Gill and NF-kappa B were found in 63 of 66 (96%), 28 of 68 (41%) and 22 of 68 cases (32%), respectively. Nuclear Gli1 expression was closely associated with nuclear expression of NF-kappa B (p < 0.001). Patients with nuclear Gli1 had significantly worse prognoses than those without (median survival 7.9 vs. 13.9 months; p = 0.009). Similarly, patients with nuclear expression of NF-kappa B had shorter overall survival than those with negative or cytoplasmic expression of NF-kappa B (median survival 5.5 vs. 13.9 months; p < 0.001). Shh expression had no prognostic significance. In the multivariate analysis, NF-kappa B nuclear expression was closely associated with unfavorable overall survival (p = 0.02). Conclusion: Our results indicate that nuclear expression of Gli1 or NF-kappa B is a strong predictor of poor prognosis in pancreatic cancer. Additional investigation of the biologic significance of this association is warranted. (C) 2013 S. Karger AG, Basel
Subjects
Pancreatic cancer
Hedgehog pathway
Nuclear factor-kappa B
Prognosis
Gemcitabine
SDGs
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