Study on the Potential Usage of Phosphatidylinositol 3-kinase/ Akt Pathway Inhibitor for the Treatment of Oral Cancer
Date Issued
2004
Date
2004
Author(s)
Yang, I-Chi
DOI
zh-TW
Abstract
Oral cancer is the fourth leading cause of cancer-related deaths in male population in Taiwan. Despite recent advances in radiotherapy and chemotherapy, the survival of patients with oral cancer has not improved significantly. Continued investigation of new chemotherapeutic agents is thus needed. Recent studies have shown that feeding rotenone inhibited carcinogen-induced mouse oral carcinogenesis. However, the mechanisms by which it inhibits oral carcinogenesis are not well understood.
We examined the effects of rotenone on proliferation, cell cycle and apoptosis of oral cancer cell lines SAS using MTT assay, flow cytometry analysis, TUNEL assay, DNA fragmentation assay and Western blotting of cleaved PARP. Rotenone significantly inhibited the proliferation of SAS oral cancer cell lines in a dose-dependent manner with a 50% inhibition concentration (IC50) of rotenone about 2.35
Subjects
口腔癌
PI3K
Akt
SDGs
Type
other
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