行政院國家科學委員會專題研究計畫期中報告:異體肢體移植後細胞素及細胞凋亡調控基因在移植物及接受者淋巴組織表現之研究（2/2）
Date Issued
2002
Date
2002
Author(s)
葉力森
DOI
902314B002403
Abstract
ALLOGRAFT rejection is associated with cytokine
production by Th-1 cells, resulting in generation of
IL-2 and INF-γ. INF-γ is am immunoregulatory
cytokine produced by CD8+ T lymphocytes, CD4+ Th
cells, and natural killer (NK) cells. INF-γinduced
MHC class II molecules on antigen-presenting cells,
activated NK cells and cytotoxic T lymphocytes, and
promotes delayed-type hypersensitivity (DTH) by
stimulating macrophages, it may mediate acute
allograft rejection and tissue necrosis1. Correlation
between rejection and up-regulation of the INF-γ
gene was observed in kidney allografts, whereas
animals with long-term tolerance showed low levels of
INF-γ2. IL-2 is produced by activated T cells and NK
cells and is the T-cell growth factors3-4. Increasing
IL-2 and INF-γgene expression was observed in rat
hind limb allograft rejection5. The aim of the study
was to compare the mRNA expression of cytokines in
rat composite tissue rejection by real-time quantitative
RT-PCR. It has been proposed that increasing INF-γ
or IL-2 gene expression may become a sensitive
rejection marker in rat composite tissue allotransplantation.
Publisher
臺北市：國立臺灣大學獸醫學系暨研究所
Type
report
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