胰島素抗阻、糖尿病與肥胖相關基因之研究
Other Title
Study on the genes related to insulin resistance, type 2 diabetes and obesity
Date Issued
2003
Date
2003
Author(s)
莊立民
DOI
913112B002019
Abstract
Type 2 diabetes is one of the most common metabolic disorders affecting at least 5%
of the whole population in the world. In Taiwan, the prevalence of diabetes mellitus
was about 4% and more than 95% of the cases were type 2 diabetes mellitus. Since
type 2 diabetes is frequently associated with obesity, hypertension, dyslipidemia and
atherosclerosis, it has been projected by the WHO that more than 75% of the health
cost will be consumed for the non-communicable disease (NCD) in the next decade.
The underlying cause of these abnormalities including type 2 diabetes, obesity,
hypertension, dyslipidemia and coronary artery disease, collectively termed
metabolic syndrome, is not well understood. However, it has been clearly shown that
both environmental and genetic factors are important in the pathogenesis of
metabolic syndrome.
In this year (of the originally proposed 3-year project), we planed to dissect
pathogenic pathways leading to the major defect underlying the metabolic syndrome,
i.e. insulin resistance. With the revision, we focus only on some the targets:
Specific research of this proposal in the first year granted:
Isolation of the SNPs of the candidate genes and confirm the association with insulin
resistance and the related clinical disorders such as type 2 diabetes, obesity and
coronary artery disease in Chinese population. We have confirmed by clinical
association studies to show a positive correlation of SNP of the APM1 gene and its
interaction with PPAR gene in subjects with obesity and insulin resistance (A study
on APM1 locus with obesity and different allelic expressions in the adipose tissue has
been accepted by JMM; A study on gene-to-gene interaction between APM1 and
PPAR has been accepted by Dia betologia). More importantly, we showed the
allele-specific expression of APM1 gene and expression of SORBS1 gene in the
adipose tissue to correlate clinical obesity and insulin sensitivity (A study on tissue
expression of SORBS1 gene correlated with clinical phenotype has been accepted by
Ob Res; A study on APM1 locus with obesity and different allelic expressions in the
adipose tissue has been accepted by JMM).
Currently, we have identified more interesting genetic markers that might be related to
clinical complex disorder such as the metabolic syndrome. Future large-scale
genotyping might yield more remarkable data via high throughput genome center.
Subjects
metabolic syndrome
mRNA expression
SNP
PPAR
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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