Early Environmental Factors, Neuropsychological Functioning, and Familial Genetic Loading of Schizophrenia
Date Issued
2005
Date
2005
Author(s)
Tseng, Yu-Hui
DOI
en-US
Abstract
Objective: To examine the relations of early environmental factors to schizophrenia of different genetic loadings. We set out to assess whether schizophrenia patients of simplex family, schizophrenia patients of multiplex family, and normal controls were different in the distributions of the early environmental factors, and whether differences in early environmental exposures were further associated with those neuropsychological functionings that have been postulated to be endophenotype of schizophrenia.
Methods: The study consisted of three groups of subjects: the simplex families (148 schizophrenic probands and 131 of their first-degree relatives), the multiplex families (73 schizophrenic probands and 29 of their first-degree relatives), and controls (n=83). The participants were interviewed in person by trained research assistants using a structured instrument, the Diagnostic Interview for Genetic Studies (DIGS), and were administered two sessions of the Continuous Performance Test (CPT) and the Wisconsin Card Sorting Test (WCST). In addition, the mothers of every family were also interviewed for information about the early environmental experiences of each offspring using scales on pregnancy history and obstetric complications.
Results: The distribution of individual complications of pregnancy and labor were not different between schizophrenic probands and their unaffected siblings in each type of simplex and multiplex family. We separate obstetric complications from antepartum and intrapartum. The result adjusted by birth order and gender is significant in “Intrapartum” (p=0.02). The expected result is significant in the expression of neuropsychological function like WCST and CPT in the schizophrenia family and control family. The comparison of WCST and CPT between probands and healthy siblings of multiplex family are not different, but it is significant in the simplex family. The scores of schizophrenic families are worse than the control family’s.
Conclusion: The distribution of proband of multiplex family is different to the simplex family and control family. The result maybe is due to different genetic loading in three families.
Subjects
產科併發症
早期環境因子
遺傳負荷
神經心理功能
schizophrenia
early environmental factor
genetic loading
neuropsychological functioning
Type
thesis
File(s)![Thumbnail Image]()
Loading...
Name
ntu-94-R92842010-1.pdf
Size
23.31 KB
Format
Adobe PDF
Checksum
(MD5):24504d815445247c6a1403813a409800