Particulate matters increase epithelial-mesenchymal transition and lung fibrosis through the ETS-1/NF-κB-dependent pathway in lung epithelial cells
Journal
Particle and fibre toxicology
Journal Volume
17
Journal Issue
1
Date Issued
2020
Author(s)
Abstract
Particulate matters (PMs) in ambient air pollution are closely related to the incidence of respiratory diseases and decreased lung function. Our previous report demonstrated that PMs-induced oxidative stress increased the expression of proinflammatory intracellular adhesion molecule-1 (ICAM-1) through the IL-6/AKT/STAT3/NF-κB pathway in A549 cells. However, the role of O-PMs in epithelial-mesenchymal transition (EMT) development and pulmonary fibrosis and the related mechanisms have not been determined. The aim of this study was to investigate the effects of O-PMs on the pathogenesis of EMT and pulmonary fibrosis as well as the expression of ETS-1 and NF-κB p65, in vitro and in vivo.
Subjects
EMT; ETS-1; Fibronectin; Particulate matters (PMs); Pulmonary fibrosis
Other Subjects
fibronectin; n acetylprolylhistidylserylcysteinylasparagine amide; transcription factor Ets 1; transcription factor RelA; uvomorulin; vimentin; fibronectin; immunoglobulin enhancer binding protein; transcription factor RelA; A-549 cell line; animal experiment; animal model; animal tissue; Article; cell migration; controlled study; epithelial mesenchymal transition; epithelium cell; human; human cell; human tissue; in vitro study; in vivo study; lung fibrosis; lung parenchyma; male; mouse; nonhuman; particulate matter; pathogenesis; priority journal; protein expression; signal transduction; air pollutant; animal; epithelial mesenchymal transition; lung; lung alveolus epithelium cell; lung fibrosis; metabolism; particulate matter; pathophysiology; toxicity; A549 Cells; Air Pollutants; Alveolar Epithelial Cells; Animals; Epithelial-Mesenchymal Transition; Fibronectins; Humans; Lung; Mice; NF-kappa B; Particulate Matter; Pulmonary Fibrosis; Transcription Factor RelA
Publisher
BMC