Association of periodontitis and oral microbiomes with Alzheimer's disease: A narrative systematic review
Journal
Journal of dental sciences
Journal Volume
17
Journal Issue
4
Pages
1762
Date Issued
2022-10
Author(s)
Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of dementia. The etiology for AD includes age, genetic susceptibility, neuropathology, and infection. Periodontitis is an infectious and inflammatory disease which mainly causes alveolar bone destruction and tooth loss. The evidence of a link between AD and periodontitis remains controversial. Thus far, studies reviewing the association between AD and periodontal disease have been insufficient from the viewpoint of the oral microbiome. The aim of this review was to focus on studies that have explored the relationship between the oral microbiome and AD development by using the next-generation sequencing technique.
Subjects
Alzheimer’s disease; Cognitive impairment; Oral microbiome; Periodontitis
SDGs
Publisher
ELSEVIER TAIWAN
Type
review