Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension
Journal
Circulation research
Journal Volume
122
Journal Issue
12
Date Issued
2018
Author(s)
Tamosiuniene, Rasa
Manouvakhova, Olga
Mesange, Paul
Saito, Toshie
Qian, Jin
Sanyal, Mrinmoy
Nguyen, Linh P
Luria, Amir
Tu, Allen B
Sante, Joshua M
Rabinovitch, Marlene
Fitzgerald, Desmond J
Graham, Brian B
Habtezion, Aida
Voelkel, Norbert F
Aurelian, Laure
Nicolls, Mark R
Abstract
Pulmonary arterial hypertension (PH) is a life-threatening condition associated with immune dysregulation and abnormal regulatory T cell (Treg) activity, but it is currently unknown whether and how abnormal Treg function differentially affects males and females.
Subjects
hypertension; prostacyclin; pulmonary sex; regulatory T cells
SDGs
Type
journal article