Patterning nanowire and micro-/nanoparticle array on micropillar-structured surface: Experiment and modeling
Journal
Biomicrofluidics
Journal Volume
4
Journal Issue
3
Date Issued
2010
Author(s)
Abstract
DNA molecules in a solution can be immobilized and stretched into a highly ordered array on a solid surface containing micropillars by molecular combing technique. However, the mechanism of this process is not well understood. In this study, we demonstrated the generation of DNA nanostrand array with linear, zigzag, and fork-zigzag patterns and the microfluidic processes are modeled based on a deforming body-fitted grid approach. The simulation results provide insights for explaining the stretching, immobilizing, and patterning of DNA molecules observed in the experiments.
Type
journal article