Primary mucosal melanoma in the nasal cavity - Report of two cases
Journal
Tzu Chi Medical Journal
Journal Volume
15
Journal Issue
1
Pages
69-74
Date Issued
2003
Author(s)
Abstract
Primary mucosal melanoma in the nasal cavity is a rare sinonasal malignancy, representing less than 1% of all melanoma. Unilateral nasal obstruction and intermittent epistaxis are the most common symptoms. Immunohistochemical stains, such as S-100 and HMB-45, are critical to the correct diagnosis. Pathological differentiation between primary and metastatic tumors is also important in making decisions about optimal management. The tumor behavior of mucosal melanoma is different from that of the cutaneous type. However, the prognosis of the former is rather poor. This paper reports on two patients with primary nasal mucosal melanoma who had nasal obstruction and epistaxis. Endoscopy revealed multiple black lesions which bled easily. Both patients had no local neck node or systemic metastasis, so they received wide excision of the tumor plus post-operative radiotherapy. One patient was well two years after surgery, but the other died of lung metastasis one year postoperatively. Conclusively, any dark-colored lesion in the nasal cavity must be carefully evaluated to disclose the histopathological nature.
SDGs
Other Subjects
protein hmb 45; protein S 100; tumor marker; unclassified drug; adult; aged; article; cancer classification; cancer diagnosis; cancer radiotherapy; cancer surgery; case report; cause of death; endoscopy; epistaxis; female; follow up; human; immunohistochemistry; lung metastasis; male; melanoma; nose cavity cancer; nose obstruction; prognosis; treatment outcome
Type
journal article