Comparative assessment of established and deep learning‐based segmentation methods for hippocampal volume estimation in brain magnetic resonance imaging analysis
Journal
NMR in Biomedicine
ISSN
0952-3480
1099-1492
Date Issued
2024-05-07
Author(s)
Hsi-Chun Wang
Chia-Sho Chen
Teng-Yi Huang
Kuei-Hong Kuo
Tzu-Chao Chuang
Yi-Ru Lin
Chung-Chin Kuo
Abstract
AbstractIn this study, our objective was to assess the performance of two deep learning‐based hippocampal segmentation methods, SynthSeg and TigerBx, which are readily available to the public. We contrasted their performance with that of two established techniques, FreeSurfer‐Aseg and FSL‐FIRST, using three‐dimensional T1‐weighted MRI scans (n = 1447) procured from public databases. Our evaluation focused on the accuracy and reproducibility of these tools in estimating hippocampal volume. The findings suggest that both SynthSeg and TigerBx are on a par with Aseg and FIRST in terms of segmentation accuracy and reproducibility, but offer a significant advantage in processing speed, generating results in less than 1 min compared with several minutes to hours for the latter tools. In terms of Alzheimer's disease classification based on the hippocampal atrophy rate, SynthSeg and TigerBx exhibited superior performance. In conclusion, we evaluated the capabilities of two deep learning‐based segmentation techniques. The results underscore their potential value in clinical and research environments, particularly when investigating neurological conditions associated with hippocampal structures.
SDGs
Publisher
Wiley
Type
journal article