Relations Between Serum Antibodies to Herpes Simplex Viruses and Sustained Attention in Schizophrenic Patients and Their Families
Date Issued
2004
Date
2004
Author(s)
Feng, Chi-Fang
DOI
en-US
Abstract
Objective: To evaluate the relations between the serological characteristics to herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) and sustained attention deficits in subjects of schizophrenic families and those of control families.
Methods: We recruited 117 schizophrenic probands and their 257 first-degree relatives, 44 control probands and their 44 mothers, and 317 unrelated population controls during the period of 2002 to 2004. Each participant’s serum immunoglobulin G class antibody titers to HSV-1 and HSV-2 were detected by means of solid-phase enzyme immunoassay with type-specific antigens, whereas part of the participants further undertook two sessions of the Continuous Performance Test (CPT). Members of the two types of families were compared for both HSV serological characteristics and CPT performance, and familial correlation in HSV infection was examined in tetrachoric correlation for categorical serostatus and in intraclass correlation coefficient for continuous antibody titers.
Results: Schizophrenic probands and their mothers had higher HSV-2 antibody titers than their counterparts in the control families, whereas no difference was found for HSV-1. When the mean antibody level of schizophrenic patients was used as the cut-off for the dichotomization of schizophrenic probands and their first-degree relatives, only patients with high HSV-1 titers were found to have poorer scores on the degraded CPT whereas other family members did not exhibit such differences. A linearly decreasing trend in HSV-1 antibody titers was further demonstrated when schizophrenic patients were trichotomized in terms of CPT scores. Prominent familial correlation in HSV-1 serostatus existed between schizophrenic probands and siblings, while moderate correlation between schizophrenic probands and mothers.
Conclusion: Our results indicate that the antibody titers to HSV-1 is associated with sustained attention deficits in schizophrenia and the infection is likely to be family-originated.
Subjects
單純疱
疹病毒第二型
精神分裂症
持續注意力
疹病毒第一型
連續操作測驗
herpes simplex virus type 2 (HSV-2)
sustained attention
continuous performance test (CPT)
schizophrenia
herpes simplex virus type 1 (HSV-1)
Type
thesis
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