Erythropoietins from teleosts
Resource
Cellular and Molecular Life Sciences, 65(22), 3545-3552
Journal
Cellular and Molecular Life Sciences
Pages
3545-3552
Date Issued
2008
Date
2008
Author(s)
Chu, C.-Y.
Cheng, C.-H.
Yang, C.-H.
Huang, C.-J.
Abstract
The epo genes of many teleosts, including zebrafish, have been cloned following the first identification of nonmammalian EPO from fugu in 2004. The zebrafish (Danio rerio) animal model is well suited for both developmental and genetic analyses for studying vertebrate erythropoiesis. The purpose of this review is to provide an update of recent progress in research on teleost EPO with a focus on its structure, expression and secretion. The EPO receptor and the downstream JAK/STAT signaling pathway are also discussed.
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