Editorial: Bioengineering systems for therapeutic and in vitro platforms
Journal
Frontiers in bioengineering and biotechnology
Journal Volume
10
Date Issued
2022
Author(s)
Abstract
The works presented in this editorial provide a wide and multidisciplinary overview of the latest strategies for the realization of bioengineered systems for therapeutic and in vitro platforms. These platforms must ensure that the tissue complexity is recapitulated and maintained to provide reliable novel scientific outcomes. The Research Topic covers various strategies for creating permissive environments, where cells can organize according to a proper architecture The use and the realization of alternative cell culture strategies also allows the fine tuning of operational parameters which offers the possibility to mimic tissue physiology and the appropriate cell niche. To accomplish this fundamental task different approaches are applied. The employment of bioactive material promotes cell material interaction at the interface thus boosting the cellular response in terms of adhesion, proliferation and differentiation. Surface functionalization enhances the performance of the tissue engineered construct by tailoring the biomaterial surface with key functional groups and moieties whose presence recapitulate the physiological surrounding. Other approaches involve the development of dynamic systems as bioreactor or chip devices The dynamic cell culture microenvironments realized there enhance nutrients transport and waste removal ensuring at the same time a proper supply of gases. The precise set up of these parameters ensure that cells are grown in a very controlled and optimized microenvironment Moreover, dynamic in vitro platform devices are quite versatile systems; indeed, their flexible control of different operational setting pave their use for the replication of cellular and extracellular features of different organs and tissue. The versatility of these multifunctional devices allows the expansion of cell types and therefore the investigation of a wide range of tissue districts, disclosing new
Subjects
biomimetic interfaces; bioreactor; disease modelling; drug testing; functional biomaterials; in vitro tools; microflluidic devices; tissue repair
Publisher
FRONTIERS MEDIA SA
Type
editorial