Precision science on incidence and progression of early-detected small breast invasive cancers by mammographic features
Journal
Cancers
Journal Volume
12
Journal Issue
7
Pages
1-14
Date Issued
2020
Author(s)
Chang R.W.-J.
Chuang S.-L.
Hsu C.-Y.
Yen A.M.-F.
Wu W.Y.-Y.
Chen S.L.-S.
Fann J.C.-Y.
Tabar L.
Smith R.A.
Duffy S.W.
Chiu S.Y.-H.
Abstract
The aim was to evaluate how the inter-screening interval affected the performance of screening by mammographic appearances. This was a Swedish retrospective screening cohort study with information on screening history and mammography features in two periods (1977-1985 and 1996-2010). The pre-clinical incidence and the mean sojourn time (MST) for small breast cancer allowing for sensitivity by mammographic appearances were estimated. The percentage of interval cancer against background incidence (I/E ratio) was used to assess the performance of mammography screening by different inter-screening intervals. The sensitivity-adjusted MSTs (in years) were heterogeneous with mammographic features, being longer for powdery and crushed stone-like calcifications (4.26, (95% CI, 3.50-5.26)) and stellate masses (3.76, (95% CI, 3.15-4.53)) but shorter for circular masses (2.65, (95% CI, 2.06-3.55)) in 1996-2010. The similar trends, albeit longer MSTs, were also noted in 1977-1985. The I/E ratios for the stellate type were 23% and 32% for biennial and triennial screening, respectively. The corresponding figures were 32% and 43% for the circular type and 21% and 29% for powdery and crushed stone-like calcifications, respectively. Mammography-featured progressions of small invasive breast cancer provides a new insight into personalized quality assurance, surveillance, treatment and therapy of early-detected breast cancer.
Publisher
MDPI AG
Type
journal article