Snp Fine Mapping of Chromosome 6p24-23 Reveals Two Potential Candidate Genes for Schizophrenia, Bmp6 and Txndc5
Resource
AMERICAN JOURNAL OF MEDICAL GENETICS PART B- NEUROPSYCHIATRIC GENETICS v.138B n.1 pp.123-124
Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B- NEUROPSYCHIATRIC GENETICS
Journal Volume
v.138B
Journal Issue
n.1
Pages
123-124
Date Issued
2005
Date
2005
Author(s)
HWU, HAI-GWO
Abstract
Introduction: There was suggestive linkage evidence of chromosome 6p24-23 to schizophrenia in our previous linkage study. Methods: In this study, we conducted a two-stage approach for further fine mapping. In the first stage, 30 single nucleotide polymorphisms (SNPs) around D6S296 with average intermarker distance of 24 kbp, and 69 SNPs around D 6S274 with average intermarker distance of 23 kbp, were selected from the public database for SNP validation in a subset of our sample. Of the 99 SNPs selected, 68 SNPs met the validation criterion of minor allele frequency above 10% . In the second stage, we genotyped the 68 validated SNPs in 216 families with at least 2 siblings affected with schizophrenia. Results: We found the SNP (rs270413) of the gene, Bone morphogenetic protein 6 (BMP 6), and the SNP (rs 13873) of thioredoxin domain containing 5 (TXNDC5) were significantly associated with schizophrenia (p < 0.05) through single locus association analysis using either Transmit or FBAT program. The haplotype block of rs270413-rs 270393 in the genomic region of BMP6 and the haplotype block of rs1225934-rs13873 in the genomic region of TXNDC5 were significantly associated with schizophrenia (p < 0.05) through haplotype association analysis. Conclusions: These results suggest that BMP6 and TXNDC5 may be potential candidate genes of schizophrenia in the 6 p24-23 region and replication in another sample is further warranted.