Animal Models of Primary Biliary Cirrhosis
Journal
Clinics in Liver Disease
Journal Volume
12
Journal Issue
2
Pages
333-347
Date Issued
2008
Author(s)
Abstract
Primary biliary cirrhosis (PBC) is well known as a disease that predominantly affects women and has been hitherto only described in humans. The absence of an animal model has significantly impaired research into both etiology and treatment. However, in the past 2 years, several spontaneous and two induced models of PBC were described. This article reviews the data on these animal models and places it in the perspective of human PBC and generic autoimmunity. ? 2008 Elsevier Inc. All rights reserved.
SDGs
Other Subjects
immunoglobulin A; immunoglobulin G; immunoglobulin M; interleukin 2 receptor alpha; clinical feature; disease course; immune response; immunoglobulin blood level; immunohistochemistry; immunopathology; major histocompatibility complex; nonhuman; primary biliary cirrhosis; review; statistical significance; T lymphocyte; Animals; Disease Models, Animal; Humans; Liver Cirrhosis, Biliary; Mice; Mice, Inbred NOD; Receptors, Interleukin-2; Receptors, Transforming Growth Factor beta
Type
review