Zerumbet Ginger Extract Attenuates Chemotherapy‐Induced Toxicity and Promotes Tumor Suppression in a Murine Breast Cancer Model
Journal
Food Science & Nutrition
Journal Volume
13
Journal Issue
12
Start Page
e71273
ISSN
2048-7177
Date Issued
2025-11-25
Author(s)
Su, Li‐Yu
Cheng, Chi‐Feng
Lee, Ming‐Chung
Chuang, Wu‐Chang
Wu, Chung‐Hsin
Abstract
Zerumbet ginger extract (ZGE) shows strong anticancer potential and enhances doxorubicin (DOX) efficacy against breast cancer while reducing its systemic toxicity. GC–MS identified zerumbone as a key bioactive. ZGE inhibited 4 T1 cell growth and tumor progression in mice and improved antioxidant activity. Combined ZGE + DOX treatment boosted antitumor effects and alleviated DOX-induced cardiotoxicity, hepatotoxicity, and nephrotoxicity, as reflected in biochemical markers. Mechanistically, ZGE suppressed TRPM2 and calcium signaling, promoting ROS-mediated apoptosis. These findings support ZGE as a promising adjuvant in breast cancer therapy.
Subjects
antioxidant activity
breast cancer
chemotherapy
doxorubicin
TRPM2 channel
zerumbet ginger extract
Publisher
John Wiley and Sons Inc
Type
journal article