Cutting edge: Insufficient perforin expression in CD8+ T cells in response to hemagglutinin from avian influenza (H5N1) virus
Journal
Journal of Immunology
Journal Volume
176
Journal Issue
8
Pages
4530-4533
Date Issued
2006
Author(s)
Abstract
Hypercytokinemia has been considered to be responsible for hemophagocytosis and multiorgan failure in severe human cases of H5N1 viral infection. In this study, we show a recombinant hemagglutinin (H5) from a H5N1 virus may suppress the perform expression and reduce cytotoxicity of human CD8+ T cells to kill H5-bearing cells. The persistence of H5-presenting cells provides sustained stimulation and leads to a marked lymphoproliferation and IFN-γ hyperproduction. We propose the IFN-γ hyperproduction may explain macrophage overactivation and sub-sequent hypercytokinemia and hemophagocytosis in severe human cases of avion influenza. Copyright ? 2006 by The American Association of Immunologists, Inc.
SDGs
Other Subjects
gamma interferon; hemagglutinin; perforin; gamma interferon; hemagglutinin, avian influenza A virus; influenza vaccine; Influenza virus hemagglutinin; membrane protein; perforin; pore forming cytotoxic protein; recombinant protein; adult; article; avian influenza; avian influenza virus; CD8+ T lymphocyte; controlled study; cytotoxicity; human; human cell; human experiment; Influenza virus; interferon production; lymphocyte proliferation; macrophage; multiple organ failure; normal human; phagocytosis; priority journal; protein expression; virus infection; virus strain; biosynthesis; cell proliferation; cytology; dendritic cell; immunology; in vitro study; Influenza virus A H5N1; kinetics; lymphocyte activation; Adult; CD8-Positive T-Lymphocytes; Cell Proliferation; Cytotoxicity, Immunologic; Dendritic Cells; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Influenza A Virus, H5N1 Subtype; Influenza Vaccines; Interferon Type II; Kinetics; Lymphocyte Activation; Membrane Glycoproteins; Pore Forming Cytotoxic Proteins; Recombinant Proteins
Publisher
American Association of Immunologists
Type
journal article