Seroepidemiologic Survey for Hepatitis B Virus Infection in Taiwan: The Effect of Hepatitis B Mass Immunization
Resource
JOURNAL OF INFECTIOUS DISEASES v.179 n.2 pp.367-370
Journal
JOURNAL OF INFECTIOUS DISEASES
Journal Volume
v.179
Journal Issue
n.2
Pages
367-370
Date Issued
1999
Date
1999
Author(s)
Hsu, Hsu?Mei
Lu, Chih?Feng
Lee, Shin?Chwen
Lin, Sheue?Rong
Chen, Ding?Shinn
Abstract
A hepatitis B mass immunization program was launched in Taiwan in July 1984, beginning with newborns of hepatitis B carrier mothers for the first 2 years of the program, which was then extended to all newborns. Seroepidemiology was studied in 3 cohorts at age 6 years. Each cohort consisted of 1500 children proportionally and randomly sampled from those entering elementary school in 1989, 1991, and 1993, representing those born 1 year before the program began and years 1 and 3 of the program, respectively. By RIA, the hepatitis B surface antigen positivity rates in the groups were 10.5%, 6.3%, and 1.7%, respectively; hepatitis B surface antibody positivity rates were 36.9%, 62.0%, 65.4%; and hepatitis B infection rates were 25.0%, 15.9%, 4.3%. Thus, universal immunization was more effective in reducing hepatitis B carriage than selective immunization of newborns of carrier mothers only. The program has proved effective in controlling chronic hepatitis B infection in Taiwan.
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